Takehiko Yokomizo Selected Research

Leukotriene B4

10/2020	Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
1/2020	Leukotriene B4 receptors as therapeutic targets for ophthalmic diseases.
1/2020	The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
1/2019	The leukotriene receptors as therapeutic targets of inflammatory diseases.
1/2019	An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin.
1/2018	Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4.
1/2018	Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
10/2017	Identification, signaling, and functions of LTB4 receptors.
1/2017	Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
1/2017	Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice.

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Takehiko Yokomizo Research Topics

Disease

27	Inflammation (Inflammations) 01/2021 - 08/2002
6	Asthma (Bronchial Asthma) 07/2019 - 10/2005
6	Neoplasms (Cancer) 01/2018 - 12/2005
4	Sepsis (Septicemia) 10/2021 - 01/2017
4	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/2020 - 01/2019
4	Wounds and Injuries (Trauma) 01/2020 - 06/2014
3	Hypersensitivity (Allergy) 01/2021 - 06/2010
3	Insulin Resistance 01/2020 - 06/2003
3	Atopic Dermatitis (Atopic Eczema) 07/2019 - 01/2019
3	Fibrosis (Cirrhosis) 01/2019 - 05/2006
3	Colitis 01/2018 - 12/2010
3	Leukemia 01/2018 - 11/2002
2	Ischemia 12/2021 - 08/2013
2	Reperfusion Injury 12/2021 - 08/2013
2	Obesity 10/2020 - 06/2003
2	Macular Degeneration (Age-Related Maculopathy) 01/2020 - 02/2015
2	Allergic Rhinitis 07/2019 - 01/2018
2	Anaphylaxis (Anaphylactic Shock) 07/2019 - 10/2016
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019 - 03/2014
2	Ureteral Obstruction 01/2019 - 01/2019
2	Pain (Aches) 10/2017 - 03/2015
2	Eosinophilia 08/2013 - 03/2013
1	Dermatitis 01/2022
1	Nociceptive Pain 01/2022
1	Renal Insufficiency (Renal Failure) 12/2021
1	Endometriosis 10/2021
1	Primary Hypertrophic Osteoarthropathy (Hypertrophic Osteoarthropathy, Primary) 09/2021
1	Allergic Contact Dermatitis 01/2021
1	Cicatrix (Scar) 11/2020
1	Mesothelioma 11/2020
1	Fatty Liver 08/2020
1	Myocardial Infarction 01/2020
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2020
1	Ulcer 01/2020
1	Crohn Disease (Crohn's Disease) 01/2020
1	Keratoconjunctivitis 01/2019
1	Infections 01/2019
1	Pruritus (Itching) 01/2019

Drug/Important Bio-Agent (IBA)

23	Leukotriene B4IBA 10/2020 - 08/2002
17	Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA 01/2021 - 10/2005
12	LipidsIBA 12/2021 - 09/2005
5	LeukotrienesIBA 07/2019 - 12/2015
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2016 - 10/2004
4	Fatty Acids (Saturated Fatty Acids)IBA 12/2021 - 01/2018
4	CytokinesIBA 01/2021 - 06/2010
3	EnzymesIBA 01/2021 - 11/2002
3	Biological ProductsIBA 11/2020 - 05/2006
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2020 - 01/2019
3	AcidsIBA 01/2019 - 03/2013
3	12-hydroxy-5,8,10-heptadecatrienoic acidIBA 10/2017 - 06/2014
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2014 - 05/2006
2	Formaldehyde (Formol)FDA Link 01/2022 - 03/2015
2	Phospholipids (Phosphatides)FDA LinkGeneric 12/2021 - 01/2018
2	EicosanoidsIBA 09/2021 - 11/2020
2	AllergensIBA 01/2021 - 03/2013
2	Indomethacin (Indometacin)FDA LinkGeneric 01/2021 - 01/2020
2	AntigensIBA 01/2021 - 10/2012
2	PapaverineIBA 12/2020 - 01/2019
2	Receptor for Advanced Glycation End ProductsIBA 12/2020 - 01/2019
2	Irinotecan (Camptosar)FDA LinkGeneric 11/2020 - 01/2018
2	Anesthetics (Anesthetic Agents)IBA 11/2019 - 01/2017
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 07/2019 - 06/2014
2	Dextran SulfateIBA 01/2018 - 02/2015
2	Pharmaceutical PreparationsIBA 01/2018 - 01/2017
2	Messenger RNA (mRNA)IBA 01/2018 - 08/2013
2	Carrier Proteins (Binding Protein)IBA 12/2016 - 01/2016
2	CalciumIBA 01/2016 - 08/2008
2	LipopolysaccharidesIBA 12/2015 - 12/2009
1	Imiquimod (Aldara)FDA LinkGeneric 01/2022
1	Liver X ReceptorsIBA 01/2022
1	Urea (Carbamide)FDA LinkGeneric 12/2021
1	CreatinineIBA 12/2021
1	salicylhydroxamic acid (SHAM)IBA 12/2021
1	Soybean Oil FDA LinkGeneric 12/2021
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2021
1	NitrogenIBA 12/2021
1	TrimebutineIBA 10/2021
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 10/2021
1	Peptide Hydrolases (Proteases)FDA Link 01/2021
1	ProstaglandinsIBA 01/2021
1	Cyclooxygenase 1IBA 01/2021
1	AntibodiesIBA 01/2021
1	Cre recombinaseIBA 01/2021
1	Thyroid HormonesIBA 10/2020
1	CatecholaminesIBA 10/2020
1	Leukotriene A4IBA 10/2020
1	leukotriene A4 hydrolaseIBA 10/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	Capsules (Microcapsules)IBA 01/2020
1	Sevoflurane (Ultane)FDA LinkGeneric 11/2019
1	HMGB1 Protein (HMG1)IBA 01/2019
1	Leukotriene C4IBA 01/2019
1	Leukotriene D4IBA 01/2019
1	Hydroxy AcidsIBA 01/2019

Therapy/Procedure

4	Ligation 11/2019 - 01/2016
3	Punctures 11/2019 - 01/2017
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020
1	General Anesthesia 11/2019